Analysis of genetic material in the ocean identifies 5,000 previously unknown viruses

A survey of mitochondrial DNA in the sea found a large number of unrecognized RNA pathogens and an increased amount of phyla; or natural families, of infections supposed to emerge.

Study of genetic material in the ocean

As a recent report published in the journal Science shows, the best-known RNA pathogens are those that induce human illnesses ranging from coughs and colds to COVID-19. They also contaminate vital flora and fauna for humans. Rather than DNA, these strains produce their hereditary data in RNA.

RNA pathogens grow much faster than DNA infections. While scientific researchers have yet cataloged a large number of viral DNA proteins in their environmental conditions, RNA infections have received little attention.

Pathogens, with the exception of living things as well as other cell-based animals, lack distinctive short segments of DNA that can serve as a molecular barcode, according to the experts’ interview with ScienceAlert.

Attempting to recognize various varieties of infection in the environment without such a barcode could be difficult. To overcome this constraint, the researchers sought to find the genome that codes for a specific enzyme allowing a pathogen to reproduce its DNA.

It is the only enzyme that all pathogens share since it is necessary for their replication. Minor changes in DNA that cause the enzyme in each opportunistic pathogen, however, can disambiguate from one type of viral infection to another.

As a result, researchers assessed a global repository of phytoplankton RNA fragments collected throughout the four-year Tara Oceans Voyages Universal Field Study.

Plankton are microscopic underwater creatures that can travel against the current. They play an important role in aquatic food connections and are popular vectors of RNA viruses. The analysis led to the identification of nearly 44,000 genetic causes of the viral enzyme. The next step was to uncover the developmental relationships between these alleles.

The greater the similarity between two sequences, the more likely infections with those genetic makeups are related. Since these patterns developed a long time ago, genetic variants showing where virus particles might have detached from a single origin were already left out.

Nonetheless, as noted on the CELL website, a type of synthetic intellectual ability known as machine learning allowed scientists to methodically organize these patterns and spot deviations objectively as if the work had been done. in a conventional way.

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Analyze the 5000 previously unknown viruses in the ocean

Analysis of these new genomes indicated that two of the new phyla were widespread across large marine areas, with geographical biases in moderate or tropical seas, the Taraviricota, named after the Tara Oceans expeditions.

Taraviricota, the scientists speculate, may be the long-sought linking element in the development of RNA viruses, uniting two identified distinct lineages of RNA viruses that differed in their mode of reproduction. These new genomes allow experts to understand not only the development of RNA viruses, but also the development of the first species on Earth.

According to the latest update from Science Direct, as demonstrated by the COVID-19 outbreak, RNA infections can induce life-threatening infections. RNA viruses, on the other hand, occupy an important place in the biosphere because they can contaminate a wide range of life forms, such as bacteria which have a neurotoxic effect on the environment and nutrient cycles.

Identifying where these RNA infections reside in the world can better explain how the viruses influence the creatures that drive many of the natural systems that make the earth work. The study also gives investigators improved techniques for cataloging new viruses as genomic collections grow.

Despite the discovery of several new RNA viruses, it remains difficult to determine which creatures they transmit. Investigators were also typically limited to fragments of inadequate RNA virus genetic sequences, due to hereditary difficulties and resource constraints.

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