Gene material – Genetic Science Services http://geneticscienceservices.com/ Tue, 20 Sep 2022 21:16:29 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://geneticscienceservices.com/wp-content/uploads/2021/10/icon-7.png Gene material – Genetic Science Services http://geneticscienceservices.com/ 32 32 Living material assembly of bacteriogenic protocells https://geneticscienceservices.com/living-material-assembly-of-bacteriogenic-protocells/ Wed, 14 Sep 2022 15:33:12 +0000 https://geneticscienceservices.com/living-material-assembly-of-bacteriogenic-protocells/ van Stevendaal, MHME, van Hest, JCM & Mason, AF Functional interactions between ascending synthetic cells and living matter for biomedical applications. ChemSystemsChem 3e2100009 (2021). Google Scholar article Jeong, S., Nguyen, HT, Kim, CH, Ly, MN, and Shin, K. Towards artificial cells: new advances in energy conversion and cell motility. Adv. Function Mater. 301907182 (2020). CAS […]]]>
  • van Stevendaal, MHME, van Hest, JCM & Mason, AF Functional interactions between ascending synthetic cells and living matter for biomedical applications. ChemSystemsChem 3e2100009 (2021).

    Google Scholar article

  • Jeong, S., Nguyen, HT, Kim, CH, Ly, MN, and Shin, K. Towards artificial cells: new advances in energy conversion and cell motility. Adv. Function Mater. 301907182 (2020).

    CAS Google Scholar Article

  • Toparlak, OD & Mansy, SS Advances in protocell synthesis. Exp. Biol. Med. 244304–313 (2018).

    Google Scholar article

  • Yewdall, NA, Mason, AF & van Hest, JCM Characteristics of living systems: towards the creation of artificial cells. Interface development 820180023 (2018).

    Google Scholar article

  • Adamala, KP, Martin-Alarcon, DA, Guthrie-Honea, KR & Boyden, ES Engineering genetic circuit interactions within and between synthetic minimal cells. Nat. Chem. 9431–439 (2017).

    CAS Google Scholar Article

  • Deng, N.-N., Yelleswarapu, M., Zheng, L. & Huck, WTS Microfluidic assembly of monodisperse vesosomes as artificial cell models. JAC 139587–590 (2017).

    CAS Google Scholar Article

  • Weiss, M. et al. Sequential bottom-up assembly of synthetic cells mechanically stabilized by microfluidics. Nat. Mater. 1789–96 (2018).

    ADS CAS Article Google Scholar

  • Huang, X. et al. Interfacial assembly of protein-polymer nanoconjugates in stimuli-responsive biomimetic protocells. Nat. Common. 42239 (2013).

    Article on Google Scholar Ads

  • Li, M., Harbron, RL, Weaver, JVM, Binks, BP & Mann, S. Electrostatically-triggered membrane permeability in inorganic protocells. Nat. Chem. 5529-536 (2013).

    CAS Google Scholar Article

  • Marguet, M., Bonduelle, C. & Lecommandoux, S. Polymeric multicompartment systems: towards biomimetic cellular structure and function. Chem. Soc. Round. 42512-529 (2013).

    CAS Google Scholar Article

  • Niederholtmeyer, H., Chaggan, C. & Devaraj, NK Communication and quorum sensing in nonliving mimics of eukaryotic cells. Nat. Common. 95027 (2018).

    Article on Google Scholar Ads

  • Kumar, BVVSP, Patil, AJ & Mann, S. Enzyme-powered motility in floating organoclay/DNA protocells. Nat. Chem. ten1154-1163 (2018).

    CAS Google Scholar Article

  • Mukwaya, V. et al. Lectin-glycan-mediated nanoparticle docking as a step toward programmable membrane catalysis and adhesion in synthetic protocells. ACS Nano 147899–7910 (2020).

    CAS Google Scholar Article

  • Dou, H. et al. Higher-order assembly of crystalline cylindrical micelles into membrane-expandable colloidosomes. Nat. Common. 8426 (2017).

    Article on Google Scholar Ads

  • Martin, N. Dynamic synthetic cells based on liquid-liquid phase separation. ChimBioChem 202553-2568 (2019).

    CAS Google Scholar Article

  • Zhang, Y. et al. Giant coacervate vesicles as an integrated approach to cytomimetic modeling. JAC 1432866–2874 (2021).

    CAS Google Scholar Article

  • Tang, T.-YD et al. Assembly of fatty acid membranes on coacervate microdroplets as a step towards a hybrid protocell model. Nat. Chem. 6527–533 (2014).

    Google Scholar article

  • Koga, S., Williams, DS, Perriman, AW & Mann, S. Peptide-nucleotide microdroplets as a step towards a membraneless protocell model. Nat. Chem. 3720–724 (2011).

    CAS Google Scholar Article

  • Tang, T.-YD, van Swaay, D., deMello, A., Ross Anderson, JL & Mann, S. In vitro gene expression in coacervated membraneless protocells. Chem. Common. 5111429–11432 (2015).

    Google Scholar article

  • Li, M., Green, DC, Anderson, JLR, Binks, BP & Mann, S. In vitro gene expression and enzyme catalysis in bio-inorganic protocells. Chem. Science. 21739-1745 (2011).

    CAS Google Scholar Article

  • Küchler, A., Yoshimoto, M., Luginbühl, S., Mavelli, F. & Walde, P. Enzymatic reactions in confined environments. Nat. Nanotechnology. 11409-420 (2016).

    Article on Google Scholar Ads

  • Strulson, CA, Molden, RC, Keating, CD & Bevilacqua, PC Catalysis of RNA by Compartmentalisation. Nat. Chem. 4941–946 (2012).

    CAS Google Scholar Article

  • Drobot, B. et al. Compartmentalized RNA catalysis in membraneless coacervate protocells. Nat. Common. 93643 (2018).

    Article on Google Scholar Ads

  • Faust, JE, Yang, P.-Y. & Huang, HW Action of antimicrobial peptides on bacterial and lipid membranes: a direct comparison. Biophys. J 1121663-1672 (2017).

    ADS CAS Article Google Scholar

  • Gray, LR, Tompkins, SC & Taylor, EB Regulation of pyruvate metabolism and human disease. Cell. Mol. Life Sci. 712577-2604 (2014).

    CAS Google Scholar Article

  • Silverman, AD, Karim, AS & Jewett, MC Cellless gene expression: an expanded repertoire of applications. Nat. Reverend Genet. 21151-170 (2020).

    CAS Google Scholar Article

  • Lee, KY et al. Artificial photosynthetic organelles support and control ATP-dependent reactions in a protocellular system. Nat. Biotechnol. 36530–535 (2018).

    CAS Google Scholar Article

  • Fung, BM & Eyob, E. The effect of ATP concentration on the rate of actin polymerization. Camber. Biochemistry. Biophys. 220370–378 (1983).

    CAS Google Scholar Article

  • Nakashima, KK, Baaij, JF & Spruijt, E. Reversible generation of coacervate droplets in an enzymatic network. soft material 14361–367 (2018).

    ADS CAS Article Google Scholar

  • Memphin, R. et al. Release of extracellular ATP by bacteria during growth. BMC Microbiol. 13301 (2013).

    Google Scholar article

  • Alvarez, CL et al. Dynamic regulation of extracellular ATP in Escherichia coli. Biochemistry. J 4741395-1416 (2017).

    CAS Google Scholar Article

  • Donau, C. et al. Active coacervation droplets as a model for membraneless organelles and protocells. Nat. Common. 115167 (2020).

    ADS CAS Article Google Scholar

  • Moreau, NG, Martin, N., Gobbo, P., Tang, TYD, and Mann, S. Spontaneous membraneless multi-compartmentation via aqueous two-phase separation in complex coacervate microdroplets. Chem. Common. 5612717–12720 (2020).

    CAS Google Scholar Article

  • Skruzny, M. et al. Molecular basis of plasma membrane coupling to the actin cytoskeleton during clathrin-mediated endocytosis. proc. Natl Acad. Science. UNITED STATES 109E2533–E2542 (2012).

    ADS CAS Article Google Scholar

  • Bosnea, LA, Moschakis, T. & Biliaderis, CG Complex coacervation as a novel microencapsulation technique to improve probiotic viability under different stresses. Food bioprocess technology. seven2767–2781 (2014).

    CAS Google Scholar Article

  • Florea, M. et al. Engineering control of bacterial cellulose production using a genetic toolbox and a new cellulose-producing strain. proc. Natl Acad. Science. UNITED STATES 113E3431–E3440 (2016).

    CAS Google Scholar Article

  • Linger, JG, Adney, WS & Darzins, A. Heterologous expression and extracellular secretion of cellulolytic enzymes by Zymomonas mobilis. Appl. About. Microbiol. 766360–6369 (2010).

    ADS CAS Article Google Scholar

  • Thakur, S., Weir, BS & Guttman, DS Plant Pathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae type and pathotype strains. Mol. Plant Microbe Interact. 29243-246 (2016).

  • Costales, MG et al. A small molecule inhibitor designed from a non-coding RNA sensitizes HER2-negative cancers to herceptin. Jam. Chem. Soc. 1412960-2974 (2019).

  • Wiechelman, KJ, Braun, RD & Fitzpatrick, JD Investigation of the bicinchoninic acid protein assay: identification of groups responsible for color formation. Anal. Biochemistry. 175231-237 (1988).

  • Drescher, HK et al. I-Selectin/CD62L is a key factor in non-alcoholic steatohepatitis in mice and humans. cells 91106 (2020).

  • Jung, Y. et al. Metabolic signature genes associated with pyruvate kinase sensitivity, muscle type 2 gene ablation in cancer cells. Mol. cells 35335–341 (2013).

  • Chiu, J., March, PE, Lee, R. & Tillett, D. Site-directed, ligase-independent mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h. Nucleic Acids Res. 32e174 (2004).

  • Berkson, J. Application of the logistic function to bioassay. Jam. Statistics Assoc. 39357–365 (1944).

    CAS Google Scholar

  • Wittrup, KD & Bailey, JE A single cell assay of β-galactosidase activity in Saccharomyces cerevisiae. Cytometry 9394–404 (1988).

    CAS Google Scholar Article

  • Spoelstra, WK, van der Sluis, EO, Dogterom, M. & Reese, L. Non-spherical coacervate forms in an active enzyme-driven system. Langmuir 361956-1964 (2020).

    CAS Google Scholar Article

  • ]]>
    TriLink BioTechnologies, Subsidiary of Maravai LifeSciences, Expands mRNA Raw Materials Offering with First GMP-Grade Modified Nucleoside Triphosphate Product https://geneticscienceservices.com/trilink-biotechnologies-subsidiary-of-maravai-lifesciences-expands-mrna-raw-materials-offering-with-first-gmp-grade-modified-nucleoside-triphosphate-product/ Tue, 13 Sep 2022 12:00:00 +0000 https://geneticscienceservices.com/trilink-biotechnologies-subsidiary-of-maravai-lifesciences-expands-mrna-raw-materials-offering-with-first-gmp-grade-modified-nucleoside-triphosphate-product/ Maravai LifeSciences Holdings LLC TriLink now offers GMP-grade N1-methyl-pseudouridine-5′-triphosphate, an essential raw material for mRNA manufacturing, enabling researchers to accelerate their drug discovery and development timelines and source United States for their supply chain SAN DIEGO, Sept. 13, 2022 (GLOBE NEWSWIRE) — TriLink BioTechnologies (TriLink), a Maravai LifeSciences (Maravai) (NASDAQ: MRVI) company and global provider […]]]>

    Maravai LifeSciences Holdings LLC

    TriLink now offers GMP-grade N1-methyl-pseudouridine-5′-triphosphate, an essential raw material for mRNA manufacturing, enabling researchers to accelerate their drug discovery and development timelines and source United States for their supply chain

    SAN DIEGO, Sept. 13, 2022 (GLOBE NEWSWIRE) — TriLink BioTechnologies (TriLink), a Maravai LifeSciences (Maravai) (NASDAQ: MRVI) company and global provider of life science reagents and services, has expanded its offering of GMP-grade products to include N1-methyl-pseudouridine-5′-triphosphate (N1meΨTP), a modified nucleoside triphosphate (NTP) essential for the manufacture of mRNA. This new product extension leverages TriLink’s quality systems and GMP capabilities, including cleanroom manufacturing, extensive analytical testing and process verification.

    The demand for N1-methyl-pseudouridine-modified mRNA has increased significantly over the past few years due to its incorporation into the two FDA-approved mRNA vaccines against COVID-19.

    “A key aspect of COVID-19 mRNA vaccines is the use of a modified base, N1-methyl-pseudouridine, instead of the standard uridine base,” said Kate Broderick, Ph.D., vice -Senior President of R&D, TriLink BioTechnologies. “This modification is essential for the mRNA vaccine to work because otherwise the delicate mRNA is rapidly degraded by the immune system.”

    TriLink was an early pioneer in this field as one of the first manufacturers of N1meΨTP. “Our team has been manufacturing N1-methyl-pseudouridine-5′-triphosphate for over a decade now, gaining considerable expertise,” said Jeremy Horton, senior vice president of manufacturing operations, TriLink BioTechnologies. “Our analytical capabilities for mRNA raw materials are unmatched, so it made strategic sense to apply this same level of process control to other products in our catalog. With its revolutionary CleanCap® co-transcriptional mRNA capping reagent, already available in billions of mRNA vaccine doses worldwide, the GMP grade N1-methyl-pseudouridine offering reinforces TriLink’s commitment to enabling industry to bring breakthrough mRNA-based therapies to the clinic.

    “N1-methyl-pseudouridine is a key starting material for the majority of mRNA-based therapies we see in development today. Our GMP-grade N1-Methyl-Pseudouridine-5′-Triphosphate allows us to meet our customers’ domestic supply needs,” said Brian Neel, Chief Operating Officer, TriLink BioTechnologies. “We are excited to add this GMP-grade molecule to our offering of capping reagents and chemically synthesized mRNA components and consider it one of many GMP-grade reagents to come in our mRNA pipeline. “

    To learn more, please visit: www.trilinkbiotech.com/modified-nucleotides.

    About Maravai

    Maravai is a leading life sciences company that provides essential products to enable the development of drug therapies, diagnostics and novel vaccines. Maravai’s companies are leaders in providing products and services in the areas of nucleic acid synthesis and biologics safety testing to many of the world’s largest companies in the fields of biopharmaceuticals, vaccines, diagnostics and cell and gene therapy.

    For more information about Maravai LifeSciences, visit www.maravai.com.

    About TriLink BioTechnologies

    TriLink BioTechnologies, part of Maravai LifeSciences, is a CDMO that helps life science leaders and innovators overcome the challenges of synthesizing and scaling up nucleic acids, NTPs and analogs of mRNA capping with scaling expertise and unique mRNA production capabilities, including its proprietary CleanCap® mRNA capping technology. TriLink continues to expand its cGMP and general manufacturing capability at its new global headquarters in San Diego, CA to support customers in mRNA, therapeutic oligonucleotides and plasmids, vaccines and diagnostics.

    For more information about TriLink, visit www.trilinkbiotech.com.

    Forward-looking statements

    This press release may contain “forward-looking statements” within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Investors are cautioned that statements contained in this press release that are not strictly forward-looking statements statements constitute forward-looking statements. , including without limitation statements related to the application for GMP grade N1-methyl-pseudouridine-5′-triphosphate and other nucleic acid products, constitute forward-looking statements identified by words such as “expect”, “may”, “anticipate”, or “could” and similar expressions. These forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated, including, without limitation, uncertainties related to the continued validation of the safety and the effectiveness of our technology, new scientific developments and the competition. from other products, and continued demand for our COVID-19 related products and services, which currently represent a significant portion of our revenues. These and other risks and uncertainties are described in more detail in the “Risk Factors” section of our most recent Annual Report on Form 10-K, as well as in other reports filed with the Securities and Exchange Commission. the United States. Actual results may differ materially from those contemplated by these forward-looking statements and, accordingly, you should not rely on them. These forward-looking statements reflect our current views, and we undertake no obligation to update any of these forward-looking statements to reflect a change in its views or events or circumstances that occur after the date hereof, except as required by law. requires it.

    CONTACT: Contact Information: Media Contact: Sara Michelmore MacDougall +1 781-235-3060 maravai@macdougall.bio Investor Contact: Deb Hart Maravai LifeSciences + 1 858-988-5917 ir@maravai.com
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    MUDVAYNE worked on new material https://geneticscienceservices.com/mudvayne-worked-on-new-material/ Thu, 08 Sep 2022 15:19:23 +0000 https://geneticscienceservices.com/mudvayne-worked-on-new-material/ Mudvayne reunited after 11 years in 2021 at the Inkcarceration Music & Tattoo Festival. Since then, the group has played in many other festivals and has even gone on tour with Rob Zombie. And just like any other reunion show for any other band, the inevitable question of “are you making another album?” arose. In […]]]>

    Mudvayne reunited after 11 years in 2021 at the Inkcarceration Music & Tattoo Festival. Since then, the group has played in many other festivals and has even gone on tour with Rob Zombie. And just like any other reunion show for any other band, the inevitable question of “are you making another album?” arose. In an interview with Revolversinger chad gray said he and the band threw riffs and saw what they could come up with.

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    “It’s obviously something we have to go through, isn’t it? There’s two ways to do it. You can go out, and you can walk around the rock once and just play catalog. Of course , that’s absolutely a possibility. Or you can try to put something together. You can evaluate it, you can decide. I’m not going to say because I’ve been constantly writing, recording tours over the last 12 years with hellyeah. So I don’t think my well is dry. And I’m excited, I’d be excited to write with these guys.

    “We did a little file sharing or whatever. Just a few riffs. Greg [Tribbett, guitar] entered the studio in Texas. He lived in Texas. He walked in there and just dropped off some stuff, sent it to Mast. Mast just put in a very simple metronome drum beat. I worked there. It’s pretty rad, different stuff. I have a few different angles that I work with, kind of like I want it to be, my parts anyway. But it’s cool, it’s cool. And obviously we’re not going to release something if I don’t feel like it’s making sense.”

    Grey later added that the new material would “fuck blow my hair back” to be released, adding that he didn’t want to disappoint fans after such a long wait between new material. When asked what the new material might sound like, drummer Matthew McDonough chimed in saying the band wouldn’t just copy his old self.

    “I can’t say honestly. Some of the stuff we messed up is heavy. We messed around with typical stuff [sounds], people wouldn’t be terribly shocked, but the opportunity to experiment and given our past successes, I think I feel a sense of freedom. There was no kind of pressure from any professional management to try to, “You’re going to write another ‘Dig’.” Or “Don’t fall” or whatever; nothing like. So the headspace and the culture around the band right now is incredibly positive. So personally, I would just like to be wide open and excited and positive about it. I want to be surprised.”

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    New Mudvayne would be the band’s first effort since their 2009 self-titled album.

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    Train employees to create a strong DE&I culture? https://geneticscienceservices.com/train-employees-to-create-a-strong-dei-culture/ Tue, 06 Sep 2022 13:28:10 +0000 https://geneticscienceservices.com/train-employees-to-create-a-strong-dei-culture/ Janine Yancey knew there had to be a better way. So in 2014, frustrated with the way the legal system was solving workplace issues, she went from helping employers defend employment claims to helping them resolve the issues that were causing those claims in the first place. . His instinct was right because currently more […]]]>

    Janine Yancey knew there had to be a better way.

    So in 2014, frustrated with the way the legal system was solving workplace issues, she went from helping employers defend employment claims to helping them resolve the issues that were causing those claims in the first place. .

    His instinct was right because currently more than 3,600 companies use his training, including Chevron, Whirlpool and Genetech.

    What makes this training system so effective? “Our method is to engage conversations, which are the real social dynamics of the workforce, using video dialogue that gets to the heart of issues of ethics, respect and inclusion. This dialogue is analyzed, aggregated and presented to employers so they can see how their workforce thinks about these issues. The next step is for the company to make changes to the culture, with the goal of everyone working together to achieve common goals,” says Janine Yancey, CEO. Train.

    A DE&I culture is required

    Reformulating a culture is often seen as a business initiative, but that perspective needs to evolve in today’s talent environment, Yancey says. “We are moving from a time when DE&I programs had an external focus whose mission was to achieve good corporate citizenship. Now, given workplace demographics and social issues, DE&I needs to be shifted to the business operations side of the organization. If you want to attract and retain talent, a DE&I culture is a must.”

    And with any business operations strategy, what gets measured gets managed. “In other areas of the business, such as production, sales and marketing, data is the foundation of strategy. The same is true for culture. It should be followed quarter to quarter and year to year. So measuring culture to make sure it’s where it needs to be is an effective way to help companies attract and retain talent. »

    Emtrain 2020 Culture Reportwhich consisted of 2.5 million responses from 40,000 employees at 125 companies, shows some of the issues employees have with their company culture:

    • 38% of employees cite in-group/out-group dynamics as the biggest source of conflict in their organization
    • 33% of employees identify power disparities as the source of the greatest level of conflict at work
    • 33% of respondents strongly agree they can be authentic themselves in the workplace

    The Emtrain System

    A company’s staff conducts a general assessment to determine their strengths and weaknesses, via the company’s CultureTech platform. It is then scored on Workplace Social Metrics and compared to a global customer data set on Workplace Culture Benchmark. Based on the data, a program is identified to strengthen areas that are weak. The courses fall into three categories; Ethics and Compliance, Respect and Harassment in the Workplace, and Equity and Diversity Inclusion and include topics such as systemic decision-making, leadership with empathy, and alliance skills.

    One company, Cisco, was so impressed with the results of the training it was delivering in-house that it announced in June 2022 that it would integrate Emtrain’s training modules through WebEx’s collaboration solutions. “Emtrain brings a lot of expert content in an innovative way that facilitates discussion around DE&I,” said Jason Copeland, vice president of product, Webex.

    Copeland says the ease of use and natural flow of information that can be integrated into collaboration tools has helped his company develop its training program. “I’ll be having a team meeting in Webex because we have a lot of people working remotely, like most companies, and we’ll be watching the videos together in real time, and then we’ll have a chat. And for people who aren’t comfortable discussing issues in a group, these videos can also be used offline. »

    Given the sensitive nature of the content, Yancey notes that it’s effective to explain things in a sensible way that provides a business case. “For example, when we talk about unconscious bias and inclusivity, we’re explaining that when you use bigger equipment, with more people who have different perspectives, the quality of decisions improves. A smaller gear, which underlies unconscious bias, is not as effective in decision making.

    In addition to improving internal culture, Copeland sees this awareness as a valuable tool in attracting employees. “As these types of discussions become natural in our daily workflow, it allows us to stay fresh and do a better job in the core activities that underpin our DE&I purpose. In turn, we can highlight these efforts when recruiting. future employees. Any company is only as good as its employees and this starts with recruitment, but it is also important for retention and development. This is how we can develop our talent to achieve good organizational results. »

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    Trump and the Art of Compromising Hardware https://geneticscienceservices.com/trump-and-the-art-of-compromising-hardware/ Mon, 05 Sep 2022 21:00:00 +0000 https://geneticscienceservices.com/trump-and-the-art-of-compromising-hardware/ When the FBI raided Donald Trump’s Mar-a-Lago estate, they found a folder titled “Info re: President of France.” Many have speculated (with little encouragement from Trump himself) that it contains illicit details about Emmanuel Macron’s sex life. Whatever the truth about this particular cache, the political kompromat has long been a source of great drama […]]]>

    When the FBI raided Donald Trump’s Mar-a-Lago estate, they found a folder titled “Info re: President of France.” Many have speculated (with little encouragement from Trump himself) that it contains illicit details about Emmanuel Macron’s sex life.

    Whatever the truth about this particular cache, the political kompromat has long been a source of great drama – both on and off screen. Some get the better of themselves – Gary Hart ruined his chances of winning the US Democratic presidential nomination in 1988 by inviting reporters to dig up dirt on him (“Follow me everywhere, put a tail on me. You you would be very boring”). They did it quickly – and the events surrounding the 51-year-old married senator’s alleged alliance with 29-year-old Donna Rice are explored in 2018. The lead runnerwith Hugh Jackman as Hart.

    The early 1960s was a particularly fertile time for films about blackmailing politicians over sexual indiscretions, possibly due to the Profumo affair in the UK and the gossip surrounding JFK’s shenanigans in the US. Here are ten of the best movies about collecting dirt on political opponents:

    Kompromat (2022) – UK release to be confirmed

    Taken from real life, this thriller by Jérôme Salle (Anthony Zimmer) with Gilles Lellouche (Don’t tell anyone) as Mathieu, a French diplomat stationed in Siberia whose support for artistic expression in the region angers authorities enough for Russian security services to concoct a false story of sexual abuse to frame him. Jailed before trial, the attaché decides to escape with his wife and daughter – a difficult decision given his location in the frozen Irkutsk Oblast in eastern Siberia. Lellouche will then play the role of Obélix in the fifth episode next year (Asterix and Obelix: The Middle Kingdom) in the Asterix action movie franchise. Guillaume Cannet (The headquarters of Jadotville) will direct and star as Asterix, with Vincent Cassel as Caesar and Marion Cotillard as Cleopatra.

    Advice and Consent (1962)

    The homosexual kompromat features as an important subplot in Otto Preminger (Laura) labyrinthine political drama centered on the nomination of Robert A. Leffingwell (Henry Fonda) as Secretary of State. There’s way too much intrigue to tell here but Advice and Consent
    well worth your time. In addition to Fonda, the cast includes Charles Laughton in a magnificent end-screen performance, Walter Pidgeon, Gene Tierney, Franchot Tones (as the sick POTUS), Don Murray (as the blackmailed senator), Betty White and George Grizzard (wonder boys) as repellent career senator Fred Van Ackerman of Wyoming.

    The best man (1964) – Amazon Buy Now

    Gore Vidal’s evergreen play was memorably brought to the screen by Franklin J. Schaffner (Patton) in a play that follows the convolutions of the American political scene of the 1960s. The best man is unique in that both candidates are likely to be turned upside down: Henry Fonda (again) as former Secretary of State William Russell and Cliff Robertson as Joe Cantwell, a Joe McCarthy-like right-winger who can having a few gay skeletons in his wartime closet.

    Seven days in May (1964)

    Kompromat figures as a last resort in John Frankenheimer (Ronin) premonitory thriller. Discovering that the populist Chairman of the Joint Chiefs of Staff, General James Mattoon Scott (Burt Lancaster), is plotting a coup, President Jordan Lyman (Fredric March) must decide to use the General’s letters against him. married to former mistress Eleanor Holbrook (Ava Gardner). . Pretty thin porridge, but the principled president fortunately has other options. An excellent image, which is worth the detour.

    The opponent (2000) – Amazon Prime, Rent/Buy

    A personal favorite, Rod Lurie (The last castle) The opponent is very much in the tradition of the three 1960s films I mentioned. Future Vice President Senator Laine Billings Hanson (Joan Allen) faces scandal when sordid footage of her apparent college participation in an initiation ritual is released. Billings refuses to confirm whether she was the woman in the photos, arguing that a male contestant would not be treated the same. Gary Oldman plays slimy Republican inquisitor Sheldon Runyon, who comes himself at the end. Jeff Bridges is excellent as Democratic Speaker Jackson Evans, as are Christian Slater as an ambitious but principled member of the House Judiciary and William Petersen (ITUC) as the deeply flawed governor of Virginia, who foolishly attempts a shortcut to national popularity.

    defense of the kingdom (1986) – Amazon Buy Now

    The late David Drury (hostile waters) underrated thriller boasts a gorgeous cast and a very plausible storyline for its time. Later, doubts surrounding Profumo’s resignation of respected MP Dennis Markham (Ian Bannen) prompted Nick Mullen (Gabriel Byrne), the reporter who published the story, to investigate further. Mullen uncovers a conspiracy surrounding US bases here and ultimate control of nuclear weapons in the UK. The cast also includes Greta Scacchi, the always superb Denholm Elliott and Robbie Coltrane in a supporting role.

    Absolute power (1997) – Amazon Rent/Buy

    Clint Eastwood’s pulpy adaptation of David Baldacci’s novel was never going to win an Oscar, but it’s a pleasantly silly watch. While hiding in a dressing room, aging master thief Luther Whitney (Eastwood) witnesses US President Alan Richmond (Gene Hackman) engaging in increasingly violent sex with his best friend’s wife (Melora Hardin), who is brought to an abrupt conclusion when the Secret Service shoots him. Whitney must decide whether to flee the country before her identity is discovered – or bring the President and his enablers to justice (sort of). The image features an unintentionally comedic scene where Whitney dresses up himself on a sweltering summer day to meet his daughter – wearing an oversized trench coat (buttoned all the way up), homburg hat and sunglasses of Sun. I guess his striped shirt and bag marked “Swag” were in the wash that day.

    bank work (2008) – STARZPLAY, Amazon Rent/Buy

    Dick Clement and Ian La Frenais (What happened to the probable boys?, Porridge, Auf Wiedersehen Pet etc.) scripted this atypical Jason Statham thriller, which takes a highly fictionalized serio-comic approach to the notorious, unsolved 1971 Baker Street bank robbery. Kompromat features heavily, with loot from thieves including naughty footage of a senior royal performing and the secretly filmed antics of senior government officials in a high-end bawdy house.

    State of play (2009) – Netflix, Amazon Rent/Buy

    This condensed film version of Paul Abbott’s 2003 BBC1 miniseries is far too conspiratorial to tackle, but suffice it to say married Congressman Stephen Collins (Ben Affleck) varied under pink the sex life and murder of his mistress leads journalist Cal McAffrey (Russell Crowe) to dig deeper. Like with Syriac (2005), the Manchurian Candidate remake (2004) and other films from the era, the military-industrial complex and private security companies feature prominently in Cal’s reporting. Abbott famously wrote State of play without knowing how it would end, which becomes apparent upon second viewing of the much-loved original series. Last year, the writer confirmed he was working on a sequel to the series.

    Gentlemen (2019) – Netflix, Amazon Rent/Buy

    If you remember “The National Anthem”, the first episode of Charlie Brooker black mirrorby Guy Ritchie Gentlemen will bring back less fond memories. Not the antics of Hugh Grant’s creepy private investigator Fletcher, but the blackmail plot hatched to compromise politically influential editor Big Dave (Eddie Marsan). I’ll leave it at that, because Big Dave’s pig encounter best not be revealed, certainly for those without a strong stomach. Suffice to say, (most) viewers won’t crave a bacon sarnie after watching the movie.

    If you’re still craving kompromat-themed movies, you might want to check out The ides of March (2011), The lives of others (2006), The Ambassador (1984) and The Necklace Affair (2001).

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    Dental Impression Materials Market to Reach $2.14 Billion Globally by 2031 at a CAGR of 9.5%: Allied Market Research https://geneticscienceservices.com/dental-impression-materials-market-to-reach-2-14-billion-globally-by-2031-at-a-cagr-of-9-5-allied-market-research/ Mon, 29 Aug 2022 11:30:00 +0000 https://geneticscienceservices.com/dental-impression-materials-market-to-reach-2-14-billion-globally-by-2031-at-a-cagr-of-9-5-allied-market-research/ Rising demand for cosmetic dentistry and rising awareness about oral health is driving the growth of the global dental impression materials market. PORTLAND, Oregon., August 29, 2022 /PRNewswire/ — Allied Market Research released a report titled “Dental Impression Materials Market By Material Type (Alginate, Silicone, Polyether, Others), By Application (Restoration & Prosthodontics, Orthodontics), By End […]]]>

    Rising demand for cosmetic dentistry and rising awareness about oral health is driving the growth of the global dental impression materials market.

    PORTLAND, Oregon., August 29, 2022 /PRNewswire/ — Allied Market Research released a report titled “Dental Impression Materials Market By Material Type (Alginate, Silicone, Polyether, Others), By Application (Restoration & Prosthodontics, Orthodontics), By End Use (Hospitals, Dental Clinics, Research Institutes & Academia): Opportunity Analysis Global and Industry Forecast, 2021-2031.“According to the report, the global dental impression materials industry was estimated at $878.10 million in 2021, and should reach $2.14 billion by 2031, registering a CAGR of 9.5% from 2022 to 2031. The report offers explicit analysis of changing market trends, major segments, major investment pockets, value chains, competitive scenarios and regional landscapes.

    Download the report (PDF of 245 pages with information, graphs, tables, figures): https://www.alliedmarketresearch.com/request-sample/17780

    Determinants of Growth-

    Rising demand for cosmetic dentistry and rising awareness about oral health is driving the growth of the global dental impression materials market. At the same time, increasing prevalence of endodontic diseases, increasing number of root canal procedures and increasing dental tourism in developing countries like China, Singapore, Indonesia, and others supplemented the growth even more. Additionally, the rise in the adoption of mouthguards by adults for various sporting activities across the globe has paved the way for lucrative opportunities in the industry.

    Covid-19 scenario-

    • The decline in the number of visits to clinics and hospitals for dental purposes has led to a decline in the demand for dental impression materials, which has negatively impacted the global dental impression materials market.
    • Low patient volumes and the postponement of elective procedures have had a direct impact on market revenue and net sales. However, the market has already started to recover at a steady pace.

    Report Scope: –

    Report attribute

    Details

    Revenue forecasts in 2030

    $2.14 billion

    Rate of growth

    CAGR of 9.5% from 2022 to 2031

    Forecast period

    2022 – 2031

    Regional scope

    North America, Europe, Asia-Pacific, Latin America, MEA

    Profiled Key Companies

    Dentsply Sirona, 3M, Dental Products Company, Keystone Industries, Henry Schein, Mitsui Chemicals, Parkell, Inc, Kettenbach GmbH & Co. KG, Ultradent Products and Zeast Dental Solutions.

    The alginate segment to keep the lion’s share

    By material, the alginates segment contributed more than three-fifths of the global dental impression materials market share in 2021 and is expected to lead by 2031. This is due to the increase in the adoption of alginate material across the world as it offers various advantages such as ease of availability, hydrophilic nature and cost effectiveness. The others segment, however, should show the Fastest CAGR of 13.0% from 2022 to 2031. Rising adoption of mouth guards among gamers to prevent various sports injuries propels the growth of the segment.

    Specific requirement on COVID-19? Ask our industry expert: https://www.alliedmarketresearch.com/request-for-customization/17780?reqfor=covid

    The segment of orthodontics to dominate by 2031-

    Based on the application, orthodontics segment generated more than half of the global dental impression materials market revenue in 2021 and is expected to lead by 2031. The same segment would also manifest CAGR the fastest of 9.8% from 2022 to 2031. is due to the increasing prevalence of endodontic diseases and dental disorders across the world.

    The segment of dental clinics to reign

    By end use, the dental clinics segment garnered more than half of the global dental impression materials market share in 2021 and is expected to maintain its dominance by 2031. The same segment is also expected to show the fastest CAGR by 9.8% from 2022 to 2031. Increase in the number of patients suffering from various dental diseases and increase in their clinic visits are driving the growth of the segment.

    North America collected most of it in 2021-

    Based on the region, North America held the major share in 2021, generating more than two-fifths of the global dental impression materials market. This is attributed to the increase in the prevalence of dental disorders due to lifestyle changes such as increased smoking habits and consumption of various fast foods among people, which ultimately leads to dental disorders. and gums. Asia Pacificsimultaneously, would gain the fastest CAGR of 10.8% by 2031. Rising patient volume, growing medical tourism, and rising personal disposable income are fueling the growth of the market.

    Inquire about purchasing:
    https://www.alliedmarketresearch.com/purchase-enquiry/17780


    Key Industry Players-

    • 3M
    • dental products company
    • Henry Schein
    • Mitsui Chemicals
    • Zeast Dental Solutions
    • Parkell, Inc.
    • Kettenbach GmbH & Co. KG
    • Dentsply Sirona
    • Key Industries
    • Ultradent products

    The report analyzes these key players of the global dental impression materials market. These players have incorporated various strategies such as expansion, new product launches, partnerships, and others to increase their market penetration and strengthen their position in the industry. The report is helpful in evaluating the operating segments, their business performance and product portfolio, etc.

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    “We have also published some syndicated market studies in the same field that you may be interested in. Below is the title of the report for your referenceconsidering the impact of Covid-19 on this market which will help you to assess the aftereffects of the pandemic on the short and long term growth trends of this market.”

    Reports on trends in the healthcare industry (book now with 10% discount + Covid-19 scenario):

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    Allied Market Research (AMR) is a full-service market research and business advisory division of Allied Analytics LLP based in Portland, OR. Allied Market Research provides global corporations as well as small and medium enterprises with unrivaled quality of “market research reports” and “Business Intelligence solutions”. AMR has a focused vision to provide business insights and advice to help its clients make strategic business decisions and achieve sustainable growth in their respective market area.

    We maintain professional relationships with various companies which helps us to extract market data which helps us to generate accurate research data tables and confirm the utmost accuracy of our market predictions. CEO of Allied Market Research Pawan Kumar is essential to inspire and encourage everyone associated with the business to maintain high quality data and help customers in every way possible to achieve success. All data presented in the reports we publish are drawn from primary interviews with senior managers of large companies in the relevant field. Our secondary data sourcing methodology includes extensive online and offline research and discussions with knowledgeable industry professionals and analysts.

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    American arrested, accused of trying to provide material support to the Islamic State https://geneticscienceservices.com/american-arrested-accused-of-trying-to-provide-material-support-to-the-islamic-state/ Sun, 28 Aug 2022 10:38:07 +0000 https://geneticscienceservices.com/american-arrested-accused-of-trying-to-provide-material-support-to-the-islamic-state/ A New Mexico man has been arrested and charged with attempting to provide material support to ISIS and shutting down an online platform that may have linked two other men to similar charges. Herman Leyvoune Wilson, 45, of Albuquerque, was arrested on Friday and will remain in custody pending arraignment in federal court on Tuesday, […]]]>

    A New Mexico man has been arrested and charged with attempting to provide material support to ISIS and shutting down an online platform that may have linked two other men to similar charges.

    Herman Leyvoune Wilson, 45, of Albuquerque, was arrested on Friday and will remain in custody pending arraignment in federal court on Tuesday, the U.S. Attorney’s Office in New Mexico said. Wilson’s newly appointed federal public defender did not immediately respond to an email seeking comment on the charges.

    For all the latest news, follow the Daily Star’s Google News channel.

    The statement from the U.S. Attorney’s Office says Wilson, also known as Bilal Mu’Min Abdullah, was indicted earlier in the week by a federal grand jury on charges related to ISIS, a Designated Foreign Terrorist Organization. by the United States.

    Federal prosecutors believe Wilson was trying to establish an ‘Islamic State Center’ in New Mexico that would teach ISIS ideology, provide martial arts training and serve as a haven for those preparing to fight for the group in the United States and abroad.

    Two men arrested in September 2020 for providing material support to ISIS testified that Wilson radicalized them to the group’s ideology. Prosecutors say Wilson then allegedly shut down an online platform that may have linked the men to his group.

    Kristopher Matthews and Jaylin Molina were arrested for providing material support to ISIS and later pleaded guilty to that charge in the Western District of Texas. Prosecutors charged them with conspiring to bomb or fire at sites including the White House and Trump Tower in New York.

    The men were later convicted in a US court in Texas. Matthews, 36, of South Carolina, was recently sentenced to 20 years in prison, and Molina, 24, of Cost, Texas, was sentenced to 18.

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    100% bio-based raw material for nylon 66 https://geneticscienceservices.com/100-bio-based-raw-material-for-nylon-66/ Fri, 26 Aug 2022 06:39:34 +0000 https://geneticscienceservices.com/100-bio-based-raw-material-for-nylon-66/ Why subscribe? If you’re a knitwear or knit fabric manufacturer looking to source the latest in knitting technology or a designer or retailer looking for knit textile inspiration, Knitting Trade Journal is the perfect resource for you. Key Benefits: Unparalleled expert industry coverage of the latest knitting technologies and industry news. Exclusive bi-monthly […]]]>

    Why subscribe?

    If you’re a knitwear or knit fabric manufacturer looking to source the latest in knitting technology or a designer or retailer looking for knit textile inspiration, Knitting Trade Journal is the perfect resource for you.

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    10 Movie Adaptations That Are Better Than Their Source Material https://geneticscienceservices.com/10-movie-adaptations-that-are-better-than-their-source-material/ Fri, 19 Aug 2022 18:00:00 +0000 https://geneticscienceservices.com/10-movie-adaptations-that-are-better-than-their-source-material/ There is a common idea that the movie is never as good as the book; some films did not receive the memo. On rare occasions, movies improve on the novel, and some stories are better suited for the big screen. RELATED: Best Book-Movie Adaptations of the 2000s These selections focused on beloved films based on […]]]>

    There is a common idea that the movie is never as good as the book; some films did not receive the memo. On rare occasions, movies improve on the novel, and some stories are better suited for the big screen.



    RELATED:

    Best Book-Movie Adaptations of the 2000s

    These selections focused on beloved films based on less acclaimed and less popular books. So some of the best movies of all time were omitted from this list because the books they adapted were just as gripping and successful. Conversely, each of these films improved upon the book and achieved greater success.

    COLLIDER VIDEO OF THE DAY

    “Die Hard” (1988)

    Although it may be the most iconic action film of the 20th century, most people are unaware that die hard was based on a 1979 novel titled Nothing lasts eternally. The film is largely faithful to the book although it adds a troubled marriage subplot and offers a less grim ending.

    The shows of Bruce Willis and Alan Rickman alone are enough to elevate the film above its source material. It’s also relentlessly entertaining, with rarely a moment that isn’t tense, emotional, or action-packed. The Christmas classic earned four Oscar nominations, a rarity for action movies, and spawned four sequels. Overall, Die Hard is one of the most scripted, best-directed, and most-viewable action films ever made.


    “Children of Men” (2006)

    children of men is a science fiction novel by PD James, published in 1992. The story centers on a dystopian future in England, where human beings have become sterile and are therefore hurtling towards extinction.

    The film took the basic story and premise but reworked its plot. Although this is usually a recipe for disaster, Alphonse CuaronThe film is considered a masterpiece by many, and even the author of the book was thrilled with the adaptation. With striking visuals, heartbreaking action sequences and an emotional spine, children of men is a must-have for fans of dystopian sci-fi.

    “Fight Club” (1999)

    Unfortunately, the first rule of fight club will have to be broken. Based on the lesser known 1996 Chuck Palahniuk novel of the same name, David FincherThe 1999 classic is largely true to its source material. Both the book and the film are often misunderstood and labeled as misogynistic and pro-violence, despite vilifying those same things. Both also offer biting critiques of consumerism and the American dream.

    However, the film became a cult classic, propelling itself to far greater fame than the book. The fantastic performances and masterful direction are a big reason for that, as is the reworked ending which was more gripping and satisfying for the audience.

    “Psycho” (1960)

    psychology is a 1959 horror novel by Robert Bloch, which tells the story of motel attendant Norman Bates and his overbearing mother. Filled with tension and shocking twists, Blotch’s novel immediately caught the attention of the legendary director Alfred Hitchcock.

    Hitchcock was largely faithful in his adaptation but added more depth to the main female character (Marion/Mary in the novel) and removed an unnecessary romantic subplot with her sister and her boyfriend. These changes, combined with its groundbreaking editing and Bernard Hermann’s signature musical score, elevated the film to legendary heights.

    RELATED:

    The Scariest Movies You Didn’t Know Were Based On Books

    ‘Jo Jo Rabbit’ (2019)

    Caged Skies is a novel about a child of the Hitler Youth who discovers that his mother is hiding a Jewish refugee. It inspired Taika Waititithe award-winning film JoJo Rabbitwhich shares the basic principle but is extremely different in tone.

    The book is a dark exploration of masculinity, social norms, obsession and bigotry. By contrast, JoJo Rabbit is a dark, comedic satire that shows how juvenile and ridiculous hatred and prejudice are. The two are interesting companions to each other, offering explorations of light and dark in equal measure. However, the film’s expert balance of humor and pathos hits harder, and the addition of Taika Waititi as JoJo’s imaginary friend version of Hitler is genius. Additionally, he portrays hate as an illogical manifestation of fear/ignorance, the impact that indoctrination can have on young people, and the sense that people can learn to change are all essential and timeless messages.


    ‘Jaws’ (1975)

    Often dubbed the world’s first blockbuster, Steven Spielbergit is Jaws was based on a 1974 novel of the same name by Pierre Benchley. Both tell the story of a great white shark that preys on tourists at a small town resort and the trials of three men trying to kill it.

    However, the book and the film are concerned with telling different themes. The film celebrates the human capacity for strength and bravery, while the book portrays men as real monsters, writing the human characters as greedy, elitist, liars. Spielberg’s film makes the central characters much more likable and cuts out major subplots involving a case and the mob. As a result, the movie is much more fun, as it’s hard not to get emotionally invested in the fates of the characters and be captivated by the epic climax. John Williams‘ the musical score is also a fantastic addition.

    RELATED:

    Steven Spielberg Movies Ranked

    “No Country for Old Men” (2007)

    There is no country for old people is a 2005 novel by Cormac McCarthy. The story concerns the aftermath of an illegal drug trade gone wrong in the desert backcountry of Texas near the Mexican border. The film is perhaps one of the most faithful adaptations of all time, as the stories are almost identical.

    However, the novel was originally written as a screenplay, which gave it an unusual and polarizing writing style that divided critics. Conversely, the Coen Brothers‘ The Best Picture winning film has the advantage thanks to Roger Deakins‘ breathtaking cinematography and the legendary performance of Javier Bardem. It also features some of the tensest scenes ever to screen, which aren’t quite as exciting on the page.

    “Forrest Gump” (1994)

    Forrest Gumpone of the most beloved films of the 1990s, was based on a 1986 novel of the same name by The groom Winston. Both share the same overarching plot: A man with a low IQ recounts all the fantastic things he’s accomplished in his adventures ranging from championship shrimp boating and ping pong to the Vietnam War and college football.

    However, the similarities end there, as the characters, ending, and themes differ. The book is fun but a little too unbalanced and chaotic and has a downright depressing ending. Robert Zemeckis wisely leaves out plenty of adventures to develop supporting characters like Jenny, Lt. Dan, and Mrs. Gump, all of whom are fleshed out more in the film. tom hankForrest’s portrayal is also much more endearing, and the film as a whole is more charming and cathartic, resulting in a huge box office comeback and six Oscars, including Best Picture.

    RELATED:

    Movies that have nothing to do with the book

    “Jurassic Park” (1993)

    jurassic park is a 1990 science fiction novel written by Michael Crichton and a 1993 film directed by Steven Spielberg. Both present to the public an amusement park where genetically recreated dinosaurs exist. While both function as thrilling action-adventure stories, they also serve as cautionary tales of genetic engineering and examples of chaos theory.

    However, the film contains a few key additions that the book cannot match: the awe-inspiring spectacle of seeing realistic dinosaurs on the big screen, John Williams’ wonderful theme song, and the charisma of Jeff Goldblum.

    “The Godfather” (1972)

    The Godfather is a detective novel by Mario Puzo, which tells the story of a fictional mafia family in New York, led by the godfather, Vito Corleone. The book is fantastic and Francis Ford CoppolaThe film wisely sticks to its story.

    However, the film still stands out as the better version, thanks to the sheer mastery on display. The direction, performance, cinematography, lighting, sound and everything else is spot on. It is rightly considered a masterpiece, earning eleven Oscar nominations and three wins, and is often ranked as one of the greatest films ever made.

    KEEP READING: Best and Worst Book in Film and TV Adaptations

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    Celltrion signs ₩110 billion raw materials supply contract with Teva Pharma https://geneticscienceservices.com/celltrion-signs-%ef%bf%a6110-billion-raw-materials-supply-contract-with-teva-pharma/ Fri, 19 Aug 2022 05:48:20 +0000 https://geneticscienceservices.com/celltrion-signs-%ef%bf%a6110-billion-raw-materials-supply-contract-with-teva-pharma/ Celltrion said it has signed a contract manufacturing organization (CMO) agreement with Teva Pharmaceutical to supply raw materials for Ajovy, a migraine drug. Celltrion has signed a CMO contract with Teva Pharmaceutical to supply raw materials for the latter’s migraine treatment, Ajovy. The contract is worth about 110 billion […]]]>

    Celltrion said it has signed a contract manufacturing organization (CMO) agreement with Teva Pharmaceutical to supply raw materials for Ajovy, a migraine drug.


    Celltrion has signed a CMO contract with Teva Pharmaceutical to supply raw materials for the latter’s migraine treatment, Ajovy.


    The contract is worth about 110 billion won ($82.8 million), 5.8% of Celltrion’s sales in 2021 and its period runs from August 19, 2022 to March 31, 2024, the company said on Friday.


    Celltrion began full-scale commercial production of Ajovy in 2017 through technology transfer and expansion of manufacturing facilities in collaboration with Teva. The latest contract will increase Teva’s cumulative payment to Celltrion for the supply of raw materials for Ajovy to approximately 335 billion won.


    “We have focused on the development and production of biopharmaceutical antibodies while maintaining friendly relations with our long-time partner Teva through the CMO contract,” said a Celltrion official. “We will do our best for sustainable growth by selectively exercising the CMO business for commodities targeting the global market to generate additional profits for the company.”


    Ajovy (ingredient: fremanezumab) is a long-acting antibody treatment that prevents headaches in patients with episodic or chronic migraine through a CGRP (calcitonin gene-related peptide) inhibitory mechanism.


    Its developer Teva is Celltrion’s partner in the North American market, marketing and selling Celltrion’s blood cancer treatment Truxima and breast cancer treatment Herjuma in the region.

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